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Diagram tracing the divergence of the operational code and the standard genetic code from a shared evolutionary origin
Adapted from an original diagram by Dr. Gustavo Caetano-Anollés, this chart traces the divergence of the “operational” code (orange) and the “standard” genetic code (blue) from a shared origin roughly 3 billion years ago. · © Gustavo Caetano-Anollés
Science When Chemistry Learned to Remember
Dr. Gustavo Caetano-Anollés on dipeptides, dual codes, and the emergence of biological meaning
One of the deepest questions in biology remains unresolved. Life depends on a translation system that converts nucleotide sequences into proteins through the genetic code. Yet the origin of that code remains uncertain. Why does life rely on two molecular languages rather than one? Why this particular mapping between codons and amino acids? Why the ribosome? For decades, the dominant explanation has been the RNA World hypothesis, which proposes that RNA preceded proteins and initially carried both informational and catalytic functions. It is an elegant framework, but mounting evidence suggests the story may be more complicated.
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Quantum physics experiment exploring whether time emerges from within a closed system
Dr. Giovanni Barontini · © University of Birmingham
Science What Time Is Made Of
An experiment suggests that time may not be fundamental, but something that emerges from within
Time is one of the most familiar aspects of human experience and one of the least understood in physics. We feel it passing. We measure it constantly. And yet some...
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Artist's impression of the Cassini spacecraft flying through the ice plumes of Enceladus
Cassini flying through the plume of Enceladus · Image: NASA/JPL-Caltech
Science The Pattern Life Leaves Behind
The search for life beyond Earth is looking in a new place: the statistical order hidden in molecules
For decades, the search for life beyond Earth has rested on a deceptively simple premise: find the right molecules. Amino acids. Fatty acids. The chemical signatures of biology...
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Encounters

Heterotrichia versicolor Eldorado National Forest, Sierra Nevada, California © Timothy Boomer

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From the Magazine
Photo.Synthetica curtain installation at Dublin Castle
Design
Architecture That Breathes
Living Architecture and the Future of Cities
In 2005, when Claudia Pasquero and Marco Poletto founded ecoLogicStudio in London, the idea that a building might breathe, metabolise, or think was largely confined to...
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Lofoten Islands, Norway, photographed by Stefano Balma
Photography
When Fog Became a Question
A Conversation with Stefano Balma
Stefano Balma’s journey into photography began with a bank of fog. Not as a metaphor, but as a visceral encounter. One day, in the forests above Genoa, a...
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Metamorphosis in Motion by Lina Ghotmeh Architecture
Architecture
Metamorphosis in Motion
Reimagining a Baroque Courtyard
There is a particular challenge in designing for a space that already knows what it is. The Cortile d'Onore of Palazzo Litta in Milan does not yield easily to new...
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